Breadcrumb
Yeongjin Gwon, PhD
The ordinal response variable will inevitably contain unknown response categories because they cannot be directly derived from published data in the literature. In this talk, we propose a statistical methodology to overcome such a common but unresolved issue in the context of network meta-regression for aggregate ordinal outcomes. Specifically, we introduce unobserved latent counts and model these counts within a Bayesian framework. The proposed approach includes several existing models as special cases and also allows us to conduct a proper statistical analysis in the presence of trials with certain missing categories. We then develop an efficient Markov chain Monte Carlo sampling algorithm to carry out Bayesian computation. A variation of the deviance information criterion is used for the assessment of goodness-of-fit under different distributions of the latent counts. A case study demonstrating the usefulness of the proposed methodology is carried out using aggregate ordinal outcome data from 17 clinical trials in treating Crohn’s Disease.